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Fmoc-NH-PEG2-C2-NH2 hydrochloride

  • CAS No. 868599-73-9

  • Cat. No. CS-0040371
  • Purity≥95%
  • MDL No.MFCD04112696

*For research and further manufacturing use only, not for direct human use.

Fmoc-NH-PEG2-C2-NH2 hydrochloride|CS-0040371

Structure of 868599-73-9

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General Information

  • CAS No. 868599-73-9
  • Cat. No. CS-0040371
  • Purity ≥95%
  • MDL No. MFCD04112696
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₇ClN₂O₄
  • Molecular Weight 406.90
  • Synonym(s) None
  • SMILES O=C(NCCOCCOCCN)OCC1C2=C(C3=C1C=CC=C3)C=CC=C2.Cl

Description

Fmoc-NH-PEG2-C2-NH2 features a dibenzofulvene (Fmoc) protecting group coupled to a short, hydrophilic PEG2 spacer and a terminal primary amine. This bifunctional scaffold enables efficient solid-phase synthesis of peptide conjugates and bioactive polymers, offering enhanced solubility and controlled chain extension under standard conditions.

Application

Fmoc-NH-PEG2-C2-NH₂ serves as a versatile bifunctional linker for peptide and protein conjugation, combining the orthogonal protection of the Fmoc group with a stable PEG2 spacer and terminal primary amine. It enables efficient solid-phase synthesis and bioconjugation workflows, offering enhanced solubility, reduced aggregation, and straightforward purification. Functions as a key building block in the construction of antibody-drug conjugates and peptide-based therapeutics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   82.81
  • LogP   2.9388
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   10

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