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Structure of 86521-05-3
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This pyridine derivative features a trimethylsilyl-protected alkyne group, enabling stable, bench-ready coupling in Sonogashira reactions. The silyl moiety enhances solubility and prevents premature reaction, while the pyridine nitrogen provides a handle for further functionalization.
2-((Trimethylsilyl)ethynyl)pyridine serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to substituted pyridine derivatives. The trimethylsilyl-protected alkyne exhibits excellent bench stability, tolerates a range of functional groups, and facilitates straightforward purification. It functions as a key intermediate in the synthesis of conjugated heterocycles and bioactive scaffolds via Sonogashira or copper-catalyzed couplings.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: