Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

[(4-Methoxyphenyl)ethynyl]trimethylsilane

  • CAS No. 3989-14-8

  • Cat. No. CS-0213704
  • Purity≥98%
  • MDL No.MFCD04039887

*For research and further manufacturing use only, not for direct human use.

[(4-Methoxyphenyl)ethynyl]trimethylsilane|CS-0213704

Structure of 3989-14-8

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 3989-14-8
  • Cat. No. CS-0213704
  • Purity ≥98%
  • MDL No. MFCD04039887
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆OSi
  • Molecular Weight 204.34
  • Synonym(s) [(4-methoxyphenyl)ethynyl](trimethyl)silane
  • SMILES C[Si](C#CC1=CC=C(OC)C=C1)(C)C

Description

This trimethylsilyl-protected alkyne features a para-methoxyphenyl group, offering enhanced solubility and stability under standard conditions. The silyl-protected acetylene integrates seamlessly into Sonogashira coupling workflows, enabling efficient access to functionalized biaryls with minimal purification overhead.

Application

[(4-Methoxyphenyl)ethynyl]trimethylsilane serves as a stable, bench-ready silyl-protected alkyne building block, enabling reliable Sonogashira coupling and other Pd-catalyzed cross-coupling reactions. Its trimethylsilyl group provides excellent functional group tolerance and facilitates purification, while the para-methoxyphenyl moiety offers enhanced solubility and compatibility in diverse synthetic workflows. This reagent functions as a key intermediate for constructing conjugated systems and heterocyclic scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • In-stock
      4-Iodoanisole|CS-W003965
      696-62-8
    • null|null
      1066-54-2
    • ~99%
    • In-stock
      [(4-Methoxyphenyl)ethynyl]trimethylsilane|CS-0213704
      3989-14-8

    References

    • Zhou, Ningzhang; Wang, Li; Thompson, David W.; Zhao, Yuming Tetrahedron, 2011 , vol. 67, # 1 p. 125 - 143
  • Route2
    • null|null
      104-92-7
    • null|null
      1066-54-2
    • ~95%
    • In-stock
      [(4-Methoxyphenyl)ethynyl]trimethylsilane|CS-0213704
      3989-14-8

    References

    • Hill, Lensey L.; Smith, Joanna M.; Brown, William S.; Moore, Lucas R.; Guevera, Paul; Pair, Emily S.; Porter, Jake; Chou, Joe; Wolterman, Christopher J.; Craciun, Raluca; Dixon, David A.; Shaughnessy, Kevin H. Tetrahedron, 2008 , vol. 64, # 29 p. 6920 - 6934
  • Route3

    References

    • Andreev, Aleksey A.; Konshin, Valeri V.; Komarov, Nikolai V.; Rubin, Michael; Brouwer, Chad; Gevorgyan, Vladimir Organic Letters, 2004 , vol. 6, # 3 p. 421 - 424

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.9241
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3989-14-8 sigma3989-14-8 manufacturer3989-14-8 price3989-14-8 structure3989-14-8 SDSbuy 3989-14-83989-14-8 supplier3989-14-8 uses3989-14-8 molecular weightprice of 3989-14-83989-14-8 chemical name formula of 3989-14-8
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label