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CS-W001157 4
Total: USD 88.00

1,4-Bis(trimethylsilyl)buta-1,3-diyne

  • CAS No. 4526-07-2

  • Cat. No. CS-W010639
  • Purity≥98%
  • MDL No.MFCD00009839

*For research and further manufacturing use only, not for direct human use.

1,4-Bis(trimethylsilyl)buta-1,3-diyne|CS-W010639

Structure of 4526-07-2

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General Information

  • CAS No. 4526-07-2
  • Cat. No. CS-W010639
  • Purity ≥98%
  • MDL No. MFCD00009839
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈Si₂
  • Molecular Weight 194.42
  • Synonym(s) 1,4-Bis(trimethylsilyl)-1,3-butadiyne
  • SMILES C[Si](C#CC#C[Si](C)(C)C)(C)C

Application

1,4-Bis(trimethylsilyl)buta-1,3-diyne serves as a stable, bench-ready building block for transition-metal-catalyzed couplings, enabling efficient access to conjugated enynes and substituted alkynes. Its dual trimethylsilyl groups enhance solubility and facilitate purification, while maintaining high functional group tolerance in Sonogashira, Glaser, and Cadiot-Chodkiewicz reactions. This reagent functions reliably in multi-step syntheses requiring selective alkyne incorporation and is particularly valuable in the construction of complex scaffolds for natural product and medicinal chemistry applications.

Synthesis

  • Route1
    • null|null
      1066-54-2
    • ~91%
    • In-stock
      1,4-Bis(trimethylsilyl)buta-1,3-diyne|CS-W010639
      4526-07-2

    References

    • Szesni, Normen; Kaiser, Melanie; Putzien, Sophie; Fischer, Richard W. Combinatorial Chemistry and High Throughput Screening, 2012 , vol. 15, # 2 p. 170 - 179
  • Route2
    • null|null
      61210-52-4
    • ~65%
    • In-stock
      1,4-Bis(trimethylsilyl)buta-1,3-diyne|CS-W010639
      4526-07-2

    References

    • Maji, Modhu Sudan; Pfeifer, Thorben; Studer, Armido Angewandte Chemie - International Edition, 2008 , vol. 47, # 49 p. 9547 - 9550
  • Route3
    • null|null
      75-77-4
    • null|null
      87-68-3
    • ~88%
    • In-stock
      1,4-Bis(trimethylsilyl)buta-1,3-diyne|CS-W010639
      4526-07-2

    References

    • Drew, Samuel L.; Lawrence, Andrew L.; Sherburn, Michael S. Angewandte Chemie - International Edition, 2013 , vol. 52, # 15 p. 4221 - 4224 Angew. Chem., 2013 , vol. 125, # 15 p. 4315 - 4318,4

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅱ
Hazard Statements : H228
Precautionary Statements : P210-P240-P241-P280-P370+P378

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.748
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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