4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine

Name: 4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 864754-18-7
Cat. No. CS-W012083
Purity≥98%
MDL No.MFCD08062342

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine|CS-W012083

Structure of 864754-18-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 864754-18-7
Cat. No. CS-W012083
Purity ≥98%
MDL No. MFCD08062342
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₆BN₃O₃
Molecular Weight 307.20
Synonym(s) 4-{2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl}morpholine
SMILES CC1(C)OB(OC1(C)C)C1=CN(CCN2CCOCC2)N=C1

Description

This morpholine-functionalized boronate ester integrates a pyrazole core with a flexible ethyl linker, enabling efficient cross-coupling in Suzuki-Miyaura reactions. The tetramethyl-1,3,2-dioxaborolane moiety ensures high stability and compatibility under standard conditions, while the electron-rich morpholine group enhances solubility and reactivity in diverse synthetic transformations.

Application

4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylborolane moiety enables robust coupling under mild conditions, while the morpholine ring provides solubility and functional group tolerance. Its stability, ease of purification, and compatibility with diverse reaction partners make it ideal for constructing complex heterocyclic scaffolds in medicinal chemistry and materials synthesis.

Synthesis

Route1
- In-stock
  
  269410-08-4
- In-stock
  
  3647-69-6
- ~%
- In-stock
  
  864754-18-7
References
- WO2010/75270 A1, ; Page/Page column 160 ; WO 2010/075270 A1
Route2
- 89583-07-3
- In-stock
  
  269410-08-4
- ~%
- In-stock
  
  864754-18-7
References
- Journal of Medicinal Chemistry, , vol. 52, # 24 p. 7934 - 7937

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 48.75
LogP 0.5145
H_Acceptors 6
H_Donors 0
Rotatable_Bonds 4

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

864754-18-7 sigma864754-18-7 manufacturer864754-18-7 price864754-18-7 structure864754-18-7 SDSbuy 864754-18-7864754-18-7 supplier864754-18-7 uses864754-18-7 molecular weightprice of 864754-18-7864754-18-7 chemical name formula of 864754-18-7

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)morpholine

CAS No. 864754-18-7

Recommended Products