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CS-W001157 4
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1-(Tetrahydro-2H-pyran-2-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

  • CAS No. 1279088-80-0

  • Cat. No. CS-0052791
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Tetrahydro-2H-pyran-2-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole|CS-0052791

Structure of 1279088-80-0

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General Information

  • CAS No. 1279088-80-0
  • Cat. No. CS-0052791
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₃BN₂O₃
  • Molecular Weight 278.16
  • Synonym(s) None
  • SMILES CC1(C)OB(OC1(C)C)C1=NN(C=C1)C1CCCCO1

Description

This pyrazole boronate ester integrates a tetrahydropyranyl protecting group and a stable dioxaborolane moiety, enabling orthogonal functionalization in complex synthesis. It delivers reliable coupling efficiency under standard Suzuki-Miyaura conditions while maintaining excellent shelf stability and moisture tolerance.

Application

1-(Tetrahydro-2H-pyran-2-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The tetrahydropyranyl (THP) group provides orthogonal protection of the pyrazole nitrogen, enabling selective functionalization and compatibility with diverse reaction conditions. Its high functional group tolerance and ease of purification make it a practical choice for constructing complex heterocyclic scaffolds in medicinal chemistry and materials synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   45.51
  • LogP   1.8814
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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