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CS-W001157 4
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3-Bromoquinoline-6-carbaldehyde

  • CAS No. 860757-84-2

  • Cat. No. CS-0133055
  • Purity≥98%
  • MDL No.MFCD28665745

*For research and further manufacturing use only, not for direct human use.

3-Bromoquinoline-6-carbaldehyde|CS-0133055

Structure of 860757-84-2

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General Information

  • CAS No. 860757-84-2
  • Cat. No. CS-0133055
  • Purity ≥98%
  • MDL No. MFCD28665745
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆BrNO
  • Molecular Weight 236.06
  • Synonym(s) Bromoquinoline-6-carbaldehyde
  • SMILES O=CC1=CC=C2N=CC(Br)=CC2=C1

Description

3-Bromoquinoline-6-carbaldehyde features a bromine substituent at the 3-position and an aldehyde group at the 6-position of the quinoline scaffold. This electron-deficient heterocycle integrates readily into cross-coupling reactions, serving as a key intermediate for bioactive molecule synthesis. The aldehyde functionality enables direct derivatization under mild conditions.

Application

3-Bromoquinoline-6-carbaldehyde serves as a versatile building block in medicinal chemistry and catalytic synthesis, enabling direct functionalization at the quinoline core. The aldehyde group facilitates nucleophilic additions, reductive aminations, and coupling reactions, while the bromine substituent supports palladium-catalyzed cross-couplings such as Suzuki and Sonogashira transformations. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.8098
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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