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CS-W001157 4
Total: USD 88.00

6-Chloro-5-fluoropicolinic acid

  • CAS No. 860296-24-8

  • Cat. No. CS-W007835
  • Molecule weight175.55
  • Purity≥98%
  • MDL No.MFCD13185819

*For research and further manufacturing use only, not for direct human use.

6-Chloro-5-fluoropicolinic acid|CS-W007835

Structure of 860296-24-8

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General Information

  • CAS No. 860296-24-8
  • Cat. No. CS-W007835
  • Purity ≥98%
  • MDL No. MFCD13185819
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClFNO₂
  • Molecular Weight 175.55
  • Synonym(s) 6-Chloro-5-fluoropyridine-2-carboxylic acid
  • SMILES O=C(O)C1=NC(Cl)=C(F)C=C1

Description

6-Chloro-5-fluoropicolinic acid features a highly electron-deficient pyridine core, enabling efficient coupling in late-stage functionalization. The ortho-chloro and meta-fluoro substituents enhance reactivity while maintaining stability under standard conditions. This scaffold integrates readily into bioactive heterocycles and serves as a key building block for pharmaceutical intermediates.

Application

6-Chloro-5-fluoropicolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its orthogonal halogenation pattern facilitates selective cross-coupling reactions, while the carboxylic acid group supports direct derivatization or amide formation. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it well-suited for scalable synthesis workflows in API development.

Synthesis

  • Route1

    References

    • SK Chemicals Co.,Ltd.; RYU, Je Ho; KIM, Shin Ae; RYU, Keun Ho; KIM, Jae Sun; KIM, Nam Ho; HAN, Hye Young; KIM, Yong Hyuk; YOUN, Won-No; LEE, Yoon-Jung; SON, Hyun Joo; LEE, Bong-yong; PARK, Sung Hoon; LEE, Ju Young; LEE, Hyun Jung; JUNG, Hoe Chul; SHIN, Young Ah; LEE, Jung A; LEE, Bo Ram; SA, Joon Ho Patent: WO2011/139107 A2, 2011 ; Location in patent: Page/Page column 83-84 ; WO 2011/139107 A2
  • Route2
    • null|null
      860296-23-7
    • ~81%
    • In-stock
      6-Chloro-5-fluoropicolinic acid|CS-W007835
      860296-24-8

    References

    • Marzi, Elena; Bobbio, Carla; Cottet, Fabrice; Schlosser, Manfred European Journal of Organic Chemistry, 2005 , # 10 p. 2116 - 2123
  • Route3
    • null|null
      860296-22-6
    • ~%
    • In-stock
      6-Chloro-5-fluoropicolinic acid|CS-W007835
      860296-24-8

    References

    • European Journal of Organic Chemistry, , # 10 p. 2116 - 2123

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5723
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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