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CS-W001157 4
Total: USD 88.00

Boc-NH-PEG4-NHS ester

  • CAS No. 859230-20-9

  • Cat. No. CS-0115267
  • Purity≥97%
  • MDL No.MFCD20228887

*For research and further manufacturing use only, not for direct human use.

Boc-NH-PEG4-NHS ester|CS-0115267

Structure of 859230-20-9

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General Information

  • CAS No. 859230-20-9
  • Cat. No. CS-0115267
  • Purity ≥97%
  • MDL No. MFCD20228887
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₃₄N₂O₁₀
  • Molecular Weight 462.49
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O

Description

Boc-NH-PEG4-NHS ester features a protected amine terminus linked to a four-ethylene glycol spacer, enabling efficient conjugation via its reactive NHS ester. This moisture-tolerant reagent facilitates site-specific labeling of proteins and biomolecules under physiological conditions, offering enhanced solubility and stability in aqueous environments.

Application

Boc-NH-PEG4-NHS ester serves as a versatile bifunctional linker for protein and peptide conjugation, enabling efficient amine coupling under physiological conditions. The NHS ester moiety reacts selectively with primary amines to form stable amide bonds, while the Boc-protected amine allows for subsequent deprotection and functionalization. Its PEG4 spacer provides enhanced solubility and reduced steric hindrance, improving conjugation efficiency in bioconjugation workflows. This reagent offers bench stability, ease of purification, and compatibility with standard synthetic protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   138.93
  • LogP   0.5748
  • H_Acceptors   10
  • H_Donors   1
  • Rotatable_Bonds   16

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