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Boc-NH-PEG2-C2-NHS ester

  • CAS No. 2183440-73-3

  • Cat. No. CS-0115144
  • Purity≥97%
  • MDL No.MFCD31381627

*For research and further manufacturing use only, not for direct human use.

Boc-NH-PEG2-C2-NHS ester|CS-0115144

Structure of 2183440-73-3

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General Information

  • CAS No. 2183440-73-3
  • Cat. No. CS-0115144
  • Purity ≥97%
  • MDL No. MFCD31381627
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₆N₂O₈
  • Molecular Weight 374.39
  • Synonym(s) None
  • SMILES CC(C)(C)OC(NCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O

Description

Boc-NH-PEG2-C2-NHS ester features a labile NHS ester for efficient coupling to primary amines, paired with a Boc-protected amine and short PEG2 spacer. This bifunctional reagent enables site-specific conjugation in biomolecule labeling and solid-phase synthesis, offering improved solubility and stability under standard conditions.

Application

Boc-NH-PEG2-C2-NHS ester serves as a versatile bifunctional linker for conjugation and polymer synthesis. The NHS ester group enables efficient coupling to primary amines under physiological conditions, while the Boc-protected amine offers orthogonal functionality for subsequent deprotection and further modification. The PEG2 spacer provides enhanced solubility and reduced steric hindrance, facilitating access to target functionalities. This reagent is bench-stable, easily purified by standard methods, and widely used in the construction of peptide-drug conjugates, bioconjugates, and functionalized polymers.

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

  • TPSA   120.47
  • LogP   0.5416
  • H_Acceptors   8
  • H_Donors   1
  • Rotatable_Bonds   10

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