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1-[3-(Pyridin-4-yl)-1,2,4-oxadiazol-5-yl]methanamine

  • CAS No. 857653-92-0

  • Cat. No. CS-0123081
  • Molecule weight176.18
  • Purity≥97%
  • MDL No.MFCD09034270

*For research and further manufacturing use only, not for direct human use.

1-[3-(Pyridin-4-yl)-1,2,4-oxadiazol-5-yl]methanamine|CS-0123081

Structure of 857653-92-0

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General Information

  • CAS No. 857653-92-0
  • Cat. No. CS-0123081
  • Purity ≥97%
  • MDL No. MFCD09034270
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₄O
  • Molecular Weight 176.18
  • Synonym(s) C-(3-Pyridin-4-yl-[1,2,4]oxadiazol-5-yl)-methylamine
  • SMILES NCC1=NC(C2=CC=NC=C2)=NO1

Description

This pyridyl-substituted oxadiazole derivative features a reactive methanamine handle for conjugation, enabling direct integration into bioconjugation workflows. The electron-deficient oxadiazole ring enhances stability under standard conditions, while the para-pyridyl group provides directional polarity for modular synthesis applications.

Application

1-[3-(Pyridin-4-yl)-1,2,4-oxadiazol-5-yl]methanamine serves as a versatile building block for constructing bioactive heterocyclic scaffolds. Its pyridyl-oxadiazole motif enables robust conjugation in medicinal chemistry campaigns, offering enhanced solubility and metabolic stability. The primary amine facilitates straightforward derivatization via amidation, alkylation, or coupling reactions. Bench-stable and readily purified by standard chromatography, it functions effectively in multi-step syntheses targeting kinase inhibitors and other targeted therapeutics.

Safety Information

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Computational Chemistry Data

  • TPSA   77.83
  • LogP   0.5903
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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