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N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-2,4,6-trisisopropylbenzenesulfonamide

  • CAS No. 852212-92-1

  • Cat. No. CS-0093717
  • Molecule weight478.69
  • Purity≥98%
  • MDL No.MFCD22988917

*For research and further manufacturing use only, not for direct human use.

N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-2,4,6-trisisopropylbenzenesulfonamide|CS-0093717

Structure of 852212-92-1

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General Information

  • CAS No. 852212-92-1
  • Cat. No. CS-0093717
  • Purity ≥98%
  • MDL No. MFCD22988917
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₃₈N₂O₂S
  • Molecular Weight 478.69
  • Synonym(s) N-((1R,2R)-2-amino-1,2-diphenylethyl)-2,4,6-triisopropylbenzenesulfonamide
  • SMILES N[C@@H]([C@H](NS(C1=C(C(C)C)C=C(C(C)C)C=C1C(C)C)(=O)=O)C2=CC=CC=C2)C3=CC=CC=C3

Description

This sulfonamide features a chiral diphenylethylamine scaffold paired with a sterically shielded trisisopropylbenzene group, delivering enhanced metabolic stability and solubility in organic media. Designed for use in asymmetric synthesis, it enables selective functionalization of reactive intermediates under mild conditions.

Application

N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-2,4,6-trisisopropylbenzenesulfonamide serves as a sterically encumbered sulfonamide building block for asymmetric synthesis. The (1R,2R)-configured aminoethyl moiety enables stereocontrolled functionalization, while the trisisopropylbenzene sulfonamide group provides exceptional steric shielding and bench stability. This scaffold facilitates selective N-alkylation and amide coupling reactions with high functional group tolerance, making it valuable for constructing complex chiral intermediates in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.19
  • LogP   6.7764
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   9

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