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N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-2,3,4,5,6-pentafluorobenzenesulfonamide

  • CAS No. 313342-24-4

  • Cat. No. CS-0011954
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-2,3,4,5,6-pentafluorobenzenesulfonamide|CS-0011954

Structure of 313342-24-4

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General Information

  • CAS No. 313342-24-4
  • Cat. No. CS-0011954
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₁₅F₅N₂O₂S
  • Molecular Weight 442.40
  • Synonym(s) N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-2,3,4,5,6-pentafluoro-BenzenesulfonaMide
  • SMILES N[C@H]([C@@H](NS(C1=C(F)C(F)=C(F)C(F)=C1F)(=O)=O)C2=CC=CC=C2)C3=CC=CC=C3

Description

N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-2,3,4,5,6-pentafluorobenzenesulfonamide features a chiral aminoethyl backbone paired with a highly electron-deficient pentafluorophenyl sulfonamide group. This combination enables precise stereochemical control in asymmetric synthesis while offering enhanced stability and solubility in organic media. The scaffold integrates readily into complex molecular architectures, facilitating efficient coupling reactions under mild conditions.

Application

N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-2,3,4,5,6-pentafluorobenzenesulfonamide serves as a versatile chiral auxiliary in asymmetric synthesis, leveraging the steric and electronic properties of the pentafluorophenyl sulfonamide group. The pendant amino functionality enables facile derivatization, while the diphenylmethyl backbone provides rigidity and enhanced stability under standard reaction conditions. Its robustness facilitates purification and broad compatibility in coupling reactions, making it a reliable scaffold for constructing complex stereodefined intermediates in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   72.19
  • LogP   4.1017
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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