N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-3,5-bis(trifluoromethyl)benzenesulfonamide

Name: N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-3,5-bis(trifluoromethyl)benzenesulfonamide
Brand: ChemScene
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CAS No. 1020665-67-1
Cat. No. CS-0092718
Purity≥98%
MDL No.None

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N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-3,5-bis(trifluoromethyl)benzenesulfonamide|CS-0092718

Structure of 1020665-67-1

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General Information

CAS No. 1020665-67-1
Cat. No. CS-0092718
Purity ≥98%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₂H₁₈F₆N₂O₂S
Molecular Weight 488.45
Synonym(s) 1R,2R-N-[3,5-bis(trifluoromethyl)]benzene sulfonamide-1,2-diphenyl ethylenediamine
SMILES N[C@@H]([C@H](NS(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)(=O)=O)C2=CC=CC=C2)C3=CC=CC=C3

Description

N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-3,5-bis(trifluoromethyl)benzenesulfonamide features a chiral amine scaffold paired with a strongly electron-deficient sulfonamide group. This combination enables precise stereochemical control in asymmetric synthesis while maintaining robust stability under standard reaction conditions. The trifluoromethyl substituents enhance lipophilicity and metabolic resistance, supporting its use in bioactive molecule development.

Application

N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-3,5-bis(trifluoromethyl)benzenesulfonamide serves as a chiral sulfonamide building block for medicinal chemistry applications. The diphenylethyl amine moiety provides stereochemical control, while the electron-deficient 3,5-bis(trifluoromethyl)benzenesulfonyl group enhances metabolic stability and modulates lipophilicity. It enables efficient incorporation into bioactive scaffolds via standard amide coupling and facilitates downstream functionalization in peptide-like or kinase inhibitor architectures.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

TPSA 72.19
LogP 5.4438
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

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N-[(1R,2R)-2-Amino-1,2-diphenylethyl]-3,5-bis(trifluoromethyl)benzenesulfonamide

CAS No. 1020665-67-1

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