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N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-2,4,6-trisisopropylbenzenesulfonamide

  • CAS No. 247923-41-7

  • Cat. No. CS-0093719
  • Purity≥98%
  • MDL No.MFCD22988918

*For research and further manufacturing use only, not for direct human use.

N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-2,4,6-trisisopropylbenzenesulfonamide|CS-0093719

Structure of 247923-41-7

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General Information

  • CAS No. 247923-41-7
  • Cat. No. CS-0093719
  • Purity ≥98%
  • MDL No. MFCD22988918
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₃₈N₂O₂S
  • Molecular Weight 478.69
  • Synonym(s) N-((1S,2S)-2-Amino-1,2-diphenylethyl)-2,4,6-triisopropylbenzenesulfonamide
  • SMILES N[C@H]([C@@H](NS(C1=C(C(C)C)C=C(C(C)C)C=C1C(C)C)(=O)=O)C2=CC=CC=C2)C3=CC=CC=C3

Description

This sulfonamide features a chiral aminoethyl scaffold paired with a sterically shielded trisisopropylbenzene group, delivering enhanced stability and solubility in organic media. The bulky isopropyl substituents minimize aggregation while the amine functionality enables facile derivatization. Designed for use in asymmetric synthesis and catalyst design, this compound combines steric protection with tunable reactivity.

Application

N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-2,4,6-trisisopropylbenzenesulfonamide serves as a sterically encumbered sulfonamide building block for asymmetric synthesis. The (1S,2S)-configured aminoethyl moiety enables stereoselective transformations, while the trisisopropylphenyl group imparts exceptional steric shielding and bench stability. This scaffold facilitates efficient amide bond formation and functions as a protected amine in multi-step sequences, offering high functional group tolerance and ease of purification in complex molecule assembly.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.19
  • LogP   6.7764
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   9

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