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CS-W001157 4
Total: USD 88.00

6-Bromo-3-methoxy-2-methylpyridine

  • CAS No. 850882-87-0

  • Cat. No. CS-0063878
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-3-methoxy-2-methylpyridine|CS-0063878

Structure of 850882-87-0

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General Information

  • CAS No. 850882-87-0
  • Cat. No. CS-0063878
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO
  • Molecular Weight 202.05
  • Synonym(s) Pyridine,6-bromo-3-methoxy-2-methyl
  • SMILES CC1=NC(Br)=CC=C1OC

Description

6-Bromo-3-methoxy-2-methylpyridine features a strategically positioned bromine atom at the 6-position, enabling direct functionalization in cross-coupling reactions. The methoxy group at C3 and methyl substituent at C2 enhance electronic modulation and solubility, while maintaining bench-stable handling under standard conditions.

Application

6-Bromo-3-methoxy-2-methylpyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its reactive bromine substituent. The methoxy and methyl groups provide orthogonal functional handles for further derivatization, while the pyridine core offers favorable electronic properties for heterocyclic scaffold elaboration. Bench-stable and readily purified by column chromatography, it functions efficiently in standard coupling protocols and supports modular synthesis of complex nitrogen-containing architectures.

Synthesis

  • Route1
    • In-stock
      6-Bromo-2-methylpyridin-3-ol|CS-W018789
      118399-86-3
    • null|null
      74-88-4
    • ~95%
    • In-stock
      6-Bromo-3-methoxy-2-methylpyridine|CS-0063878
      850882-87-0

    References

    • Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
  • Route2
    • In-stock
      6-Bromo-2-methylpyridin-3-ol|CS-W018789
      118399-86-3
    • null|null
      18107-18-1
    • ~91%
    • In-stock
      6-Bromo-3-methoxy-2-methylpyridine|CS-0063878
      850882-87-0

    References

    • Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724
  • Route3

    References

    • Klumpp, Cedric; Burger, Alain; Mislin, Gaetan L.; Abdallah, Mohamed A. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1721 - 1724

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.16112
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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