tert-Butyl 3-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate

Name: tert-Butyl 3-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 849547-86-0
Cat. No. CS-0096156
Purity≥97%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate|CS-0096156

Structure of 849547-86-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 849547-86-0
Cat. No. CS-0096156
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₄N₂O₄
Molecular Weight 272.34
Synonym(s) 4-[(1,1-Dimethylethoxy)carbonyl]-2-piperazineacetic acid ethyl ester
SMILES O=C(OCC)CC1NCCN(C(OC(C)(C)C)=O)C1

Description

tert-Butyl 3-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate features a piperazine core functionalized with an ethoxyacetyl group, enabling direct incorporation into bioactive molecule synthesis. The tert-butyl ester provides stable protection under standard conditions, facilitating selective deprotection during late-stage modifications. This scaffold serves as a key building block for pharmaceutical intermediates requiring polar, nitrogen-rich motifs with controlled reactivity.

Application

tert-Butyl 3-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate serves as a versatile piperazine-based building block for medicinal chemistry and process development. The ethoxyketone functionality enables selective nucleophilic additions and reductive transformations, while the tert-butoxycarbonyl (Boc) group provides orthogonal protection compatible with standard deprotection protocols. Its bench-stable nature and ease of purification support scalable synthesis of bioactive molecules, particularly in the construction of heterocyclic scaffolds common in kinase inhibitors and CNS-targeted therapeutics.

Synthesis

Route1
- 162510-50-1
- ~%
- In-stock
  
  849547-86-0
References
- Malancona, Savina; Altamura, Sergio; Filocamo, Gessica; Kinzel, Olaf; Hernando, Jose Ignacio Martin; Rowley, Michael; Scarpelli, Rita; Steinkuehler, Christian; Jones, Philip Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4422 - 4428

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 67.87
LogP 1.1485
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

849547-86-0 sigma849547-86-0 manufacturer849547-86-0 price849547-86-0 structure849547-86-0 SDSbuy 849547-86-0849547-86-0 supplier849547-86-0 uses849547-86-0 molecular weightprice of 849547-86-0849547-86-0 chemical name formula of 849547-86-0

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

tert-Butyl 3-(2-ethoxy-2-oxoethyl)piperazine-1-carboxylate

CAS No. 849547-86-0

Recommended Products