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(S)-tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate

  • CAS No. 1273577-11-9

  • Cat. No. CS-0079172
  • Purity≥95%
  • MDL No.MFCD18633590

*For research and further manufacturing use only, not for direct human use.

(S)-tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate|CS-0079172

Structure of 1273577-11-9

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General Information

  • CAS No. 1273577-11-9
  • Cat. No. CS-0079172
  • Purity ≥95%
  • MDL No. MFCD18633590
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₃
  • Molecular Weight 230.31
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCN[C@@H](CCO)C1

Description

(S)-tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate features a chiral piperazine core with a pendant hydroxyethyl side chain, enabling selective conjugation in peptide and kinase inhibitor synthesis. The tert-butyl ester group provides stability and convenient deprotection under mild acidic conditions, while the hydroxyl moiety offers ready derivatization for bioconjugation or solubility enhancement in polar media.

Application

(S)-tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to piperazine-based scaffolds. The pendant hydroxyl group facilitates downstream functionalization via esterification, etherification, or oxidation, while the tert-butyl carbamate provides stability and convenient deprotection under mild acidic conditions. Its stereochemical integrity supports asymmetric synthesis, and the molecule exhibits excellent bench stability and ease of purification—ideal for iterative library construction and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   61.8
  • LogP   0.5777
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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