tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate

Name: tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1188265-73-7
Cat. No. CS-0079657
Purity≥95%
MDL No.MFCD13152268

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate|CS-0079657

Structure of 1188265-73-7

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General Information

CAS No. 1188265-73-7
Cat. No. CS-0079657
Purity ≥95%
MDL No. MFCD13152268
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₂N₂O₃
Molecular Weight 230.30
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CCNC(CCO)C1

Description

tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate features a hydroxylated piperazine scaffold that enables direct functionalization in late-stage synthesis. The protected amine and pendant alcohol facilitate modular derivatization, while the tert-butyl group ensures stability under standard conditions. This bifunctional building block integrates seamlessly into medicinal chemistry campaigns requiring polar, flexible linkers.

Application

tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the efficient installation of piperazine scaffolds with orthogonal functionalization. The pendant hydroxyl group facilitates derivatization via esterification, etherification, or protection, while the tert-butyl carbamate ensures stability and ease of removal under mild acidic conditions. Its compatibility with standard coupling reactions and favorable solubility profile make it well-suited for both small-molecule synthesis and API intermediate development.

Synthesis

Route1
- In-stock
  
  183742-33-8
- ~%
- In-stock
  
  1188265-73-7
References
- MERCK SHARP and DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong Patent: WO2013/28474 A1, 2013 ; Location in patent: Page/Page column 49 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 61.8
LogP 0.5777
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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tert-Butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate

CAS No. 1188265-73-7

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