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CS-W001157 4
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6-Hydroxy-2,3-dihydro-1H-inden-1-one

  • CAS No. 62803-47-8

  • Cat. No. CS-W007571
  • Purity≥98%
  • MDL No.MFCD00513530

*For research and further manufacturing use only, not for direct human use.

6-Hydroxy-2,3-dihydro-1H-inden-1-one|CS-W007571

Structure of 62803-47-8

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General Information

  • CAS No. 62803-47-8
  • Cat. No. CS-W007571
  • Purity ≥98%
  • MDL No. MFCD00513530
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈O₂
  • Molecular Weight 148.16
  • Synonym(s) 6-Hydroxy-1-Indenone
  • SMILES O=C1CCC2=C1C=C(O)C=C2

Description

6-Hydroxy-2,3-dihydro-1H-inden-1-one features a fused bicyclic core with a strategically positioned hydroxyl group, enabling direct functionalization at the 6-position. This electron-rich scaffold serves as a key intermediate in synthesizing bioactive indenone derivatives and natural product analogs. The compound exhibits good stability under standard bench conditions and facilitates efficient coupling reactions without requiring protective group manipulation.

Application

6-Hydroxy-2,3-dihydro-1H-inden-1-one serves as a versatile scaffold for the synthesis of bioactive heterocycles and natural product analogs. Its hydroxyl and ketone functionalities enable selective derivatization via oxidation, protection, or coupling reactions. The molecule exhibits bench stability and facilitates straightforward purification, making it well-suited for iterative medicinal chemistry campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • Wang, Bo; Zhang, Lijuan; Fu, Kaiyong; Luo, Yu; Lu, Wei; Tang, Jie Organic Preparations and Procedures International, 2009 , vol. 41, # 4 p. 309 - 314
  • Route2
    • null|null
      1313762-42-3
    • ~96%
    • In-stock
      6-Hydroxy-2,3-dihydro-1H-inden-1-one|CS-W007571
      62803-47-8

    References

    • Vautravers, Nicolas R.; Regent, Damien D.; Breit, Bernhard Chemical Communications, 2011 , vol. 47, # 23 p. 6635 - 6637
  • Route3

    References

    • Farmaco, Edizione Scientifica, , vol. 38, # 3 p. 167 - 172

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H317-H319
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.5211
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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