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CS-W001157 4
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(3-((3,5-Dimethoxybenzyl)oxy)-2,6-difluorophenyl)boronic acid

  • CAS No. 849062-01-7

  • Cat. No. CS-0119985
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-((3,5-Dimethoxybenzyl)oxy)-2,6-difluorophenyl)boronic acid|CS-0119985

Structure of 849062-01-7

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General Information

  • CAS No. 849062-01-7
  • Cat. No. CS-0119985
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₅BF₂O₅
  • Molecular Weight 324.08
  • Synonym(s) 2,6-Difluoro-3-(3',5'-dimethoxybenzyloxy)phenylboronic acid
  • SMILES OB(C1=C(F)C=CC(OCC2=CC(OC)=CC(OC)=C2)=C1F)O

Description

This boronate moiety features a 3,5-dimethoxybenzyl ether-protected phenolic scaffold with difluorinated aryl substitution, enabling stable incorporation into Suzuki-Miyaura coupling workflows. The electron-rich dimethoxy group enhances reactivity while the fluorine atoms improve metabolic stability and modulate electronic properties. Designed for efficient late-stage functionalization in complex molecule synthesis.

Application

(3-((3,5-Dimethoxybenzyl)oxy)-2,6-difluorophenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. The ortho-difluoro substitution enhances electrophilic reactivity and metabolic stability, while the protected phenolic ether facilitates purification and handling. Its bench-stable boronic acid functionality supports scalable synthesis and integration into complex molecular scaffolds relevant to medicinal chemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   68.15
  • LogP   1.2408
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   6

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