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CS-W001157 4
Total: USD 88.00

3-(Benzyloxy)benzoic acid

  • CAS No. 69026-14-8

  • Cat. No. CS-0071355
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Benzyloxy)benzoic acid|CS-0071355

Structure of 69026-14-8

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General Information

  • CAS No. 69026-14-8
  • Cat. No. CS-0071355
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂O₃
  • Molecular Weight 228.24
  • Synonym(s) benzoic acid, 3-(phenylmethoxy)-
  • SMILES O=C(O)C1=CC=CC(OCC2=CC=CC=C2)=C1

Description

3-(Benzyloxy)benzoic acid features a benzyloxy-substituted aromatic ring paired with a carboxylic acid group, enabling direct conjugation in bioconjugation workflows. The benzyl ether linkage offers stability under standard reaction conditions while allowing selective cleavage when required. This dual functionality supports integration into complex molecular architectures with predictable reactivity and enhanced solubility in organic solvents.

Application

3-(Benzyloxy)benzoic acid serves as a versatile building block for bioactive molecule synthesis, enabling direct incorporation of both phenolic and carboxylic acid functionalities. Its benzyloxy group provides orthogonal protection for hydroxyls during synthetic sequences, while the carboxylic acid facilitates amide coupling, esterification, or metal-mediated transformations. The compound exhibits excellent bench stability, simplifies purification by chromatography, and functions reliably in standard heterocycle assembly and medicinal chemistry workflows.

Synthesis

  • Route1
    • Methyl 3-(benzyloxy)benzoate|CS-0195937
      79678-37-8
    • ~98%
    • In-stock
      3-(Benzyloxy)benzoic acid|CS-0071355
      69026-14-8

    References

    • UNIVERSITY OF GREENWICH Patent: WO2009/90431 A1, 2009 ; Location in patent: Page/Page column 34 ; WO 2009/090431 A1
  • Route2
    • null|null
      100-39-0
    • In-stock
      3-Hydroxybenzoic acid|CS-W004049
      99-06-9
    • ~65%
    • In-stock
      3-(Benzyloxy)benzoic acid|CS-0071355
      69026-14-8

    References

    • KUOPION YLIOPISTO Patent: WO2008/129129 A1, 2008 ; Location in patent: Page/Page column 31-32 ; WO 2008/129129 A1
  • Route3
    • null|null
      54396-39-3
    • ~%
    • In-stock
      3-(Benzyloxy)benzoic acid|CS-0071355
      69026-14-8

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 7 p. 2191 - 2194

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335-H410
Precautionary Statements : P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.9638
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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