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CS-W001157 4
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(4-(tert-Butoxy)phenyl)methanamine

  • CAS No. 84697-13-2

  • Cat. No. CS-W017253
  • Purity≥98%
  • MDL No.MFCD06213869

*For research and further manufacturing use only, not for direct human use.

(4-(tert-Butoxy)phenyl)methanamine|CS-W017253

Structure of 84697-13-2

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General Information

  • CAS No. 84697-13-2
  • Cat. No. CS-W017253
  • Purity ≥98%
  • MDL No. MFCD06213869
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇NO
  • Molecular Weight 179.26
  • Synonym(s) 4-tert-Butoxybenzylamine
  • SMILES CC(C)(C)OC1=CC=C(CN)C=C1

Description

This bench-stable arylamine features a tert-butoxy group that enhances solubility and steric protection, enabling efficient coupling in amine-directed synthetic transformations. The para-tert-butoxy substitution pattern imparts electron-donating character, stabilizing intermediates during catalytic processes.

Application

(4-(tert-Butoxy)phenyl)methanamine serves as a versatile arylalkyl amine building block, enabling efficient access to biologically relevant scaffolds through standard coupling and functionalization reactions. The tert-butoxy group provides steric shielding and enhances solubility, while the primary amine facilitates conjugation with electrophiles, including acyl chlorides, aldehydes, and isocyanates. Its bench-stable nature and compatibility with common protecting group strategies make it ideal for multi-step synthesis in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Keller, Max; Pop, Nathalie; Hutzler, Christoph; Beck-Sickinger, Annette G.; Bernhardt, Guenther; Buschauer, Armin Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 8168 - 8172
  • Route2
    • null|null
      507-20-0
    • In-stock
      4-Hydroxybenzylamine|CS-W004078
      696-60-6
    • ~87%
    • In-stock
      (4-(tert-Butoxy)phenyl)methanamine|CS-W017253
      84697-13-2

    References

    • Bandgar; Kasture Journal of Chemical Research - Part S, 2000 , # 5 p. 252 - 253
  • Route3
    • 4-Cyanophenol Febuxostat Impurity|CS-0213981
      767-00-0
    • ~%
    • In-stock
      (4-(tert-Butoxy)phenyl)methanamine|CS-W017253
      84697-13-2

    References

    • Chemistry - A European Journal, , vol. 4, # 8 p. 1570 - 1580

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.3226
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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