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CS-W001157 4
Total: USD 88.00

5-Azaspiro[3.4]octan-6-one

  • CAS No. 84565-28-6

  • Cat. No. CS-0197449
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Azaspiro[3.4]octan-6-one|CS-0197449

Structure of 84565-28-6

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General Information

  • CAS No. 84565-28-6
  • Cat. No. CS-0197449
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁NO
  • Molecular Weight 125.17
  • Synonym(s) None
  • SMILES O=C(CC1)NC21CCC2

Description

5-Azaspiro[3.4]octan-6-one features a rigid, bicyclic scaffold with a nitrogen atom integrated into the spiro ring system, providing enhanced metabolic stability and improved solubility profile. This structural motif serves as a key building block in medicinal chemistry for accessing bioactive heterocycles, particularly in CNS-targeted compound libraries.

Application

5-Azaspiro[3.4]octan-6-one serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization protocols. Its spirocyclic architecture provides conformational rigidity and enhanced metabolic stability, while the ketone and nitrogen functionalities offer sites for selective derivatization. The compound exhibits excellent bench stability and compatibility with common coupling reactions, facilitating efficient access to complex molecular architectures in lead optimization campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.8191
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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