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CS-W001157 4
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Spiro[3.5]nonane-6,8-dione

  • CAS No. 221342-48-9

  • Cat. No. CS-0047213
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Spiro[3.5]nonane-6,8-dione|CS-0047213

Structure of 221342-48-9

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General Information

  • CAS No. 221342-48-9
  • Cat. No. CS-0047213
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂O₂
  • Molecular Weight 152.19
  • Synonym(s) 5,5-spirocyclobutylcyclohexane-1,3-dione
  • SMILES O=C(C1)CC2(CC1=O)CCC2

Description

Spiro[3.5]nonane-6,8-dione features a rigid, polycyclic scaffold with two carbonyl groups at the spiro junction, enhancing its structural stability and enabling selective functionalization. This configuration supports its utility in asymmetric synthesis and as a chiral building block for complex molecular architectures.

Application

Spiro[3.5]nonane-6,8-dione serves as a rigid, bicyclic scaffold for medicinal chemistry and natural product synthesis. Its 1,3-dicarbonyl functionality enables enolization and nucleophilic addition reactions, facilitating C–C bond formation under mild conditions. The spirocyclic core provides defined stereochemistry and conformational restraint, enhancing metabolic stability in target-directed libraries. Bench-stable and amenable to derivatization via standard carbonyl transformations, it functions as a versatile building block in multistep synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   1.4788
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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