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CS-W001157 4
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(1S,2S)-2-Aminocyclopentane-1-carboxylic acid

  • CAS No. 64191-13-5

  • Cat. No. CS-0130164
  • Purity≥95%
  • MDL No.MFCD09749904

*For research and further manufacturing use only, not for direct human use.

(1S,2S)-2-Aminocyclopentane-1-carboxylic acid|CS-0130164

Structure of 64191-13-5

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General Information

  • CAS No. 64191-13-5
  • Cat. No. CS-0130164
  • Purity ≥95%
  • MDL No. MFCD09749904
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO₂
  • Molecular Weight 129.16
  • Synonym(s) (1S,2S)-2-Aminocyclopentanecarboxylic acid
  • SMILES O=C([C@@H]1[C@@H](N)CCC1)O

Description

(1S,2S)-2-Aminocyclopentane-1-carboxylic acid features a rigid, chiral cyclopentane scaffold with adjacent amine and carboxylic acid functionalities. This configuration imparts high stereochemical fidelity, enabling precise integration into peptidomimetic scaffolds and bioactive molecule design. The compound exhibits favorable solubility and stability under standard bench conditions.

Application

(1S,2S)-2-Aminocyclopentane-1-carboxylic acid serves as a stereochemically defined building block for bioactive molecule synthesis, enabling efficient access to cyclopentane-based peptidomimetics and heterocyclic scaffolds. Its stable chiral framework exhibits excellent functional group tolerance, facilitates straightforward purification, and supports diverse coupling reactions in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H. Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073
  • Route2
    • (1s,2s)-2-(((s)-1-Phenylethyl)amino)cyclopentane-1-carboxylic acid|CS-0663716
      359586-68-8
    • ~%
    • In-stock
      (1S,2S)-2-Aminocyclopentane-1-carboxylic acid|CS-0130164
      64191-13-5

    References

    • Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H. Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073
  • Route3
    • Ethyl (1S,2S)-2-(((S)-1-phenylethyl)amino)cyclopentane-1-carboxylate|CS-0451663
      359586-66-6
    • ~%
    • In-stock
      (1S,2S)-2-Aminocyclopentane-1-carboxylic acid|CS-0130164
      64191-13-5

    References

    • Pokorski, Jonathan K.; Witschi, Mark A.; Purnell, Bethany L.; Appella, Daniel H. Journal of the American Chemical Society, 2004 , vol. 126, # 46 p. 15067 - 15073

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.1984
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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