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CS-W001157 4
Total: USD 88.00

2,3-Dimethylindoline

  • CAS No. 22120-50-9

  • Cat. No. CS-0137235
  • Molecule weight147.22
  • Purity≥95%
  • MDL No.MFCD00005707

*For research and further manufacturing use only, not for direct human use.

2,3-Dimethylindoline|CS-0137235

Structure of 22120-50-9

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General Information

  • CAS No. 22120-50-9
  • Cat. No. CS-0137235
  • Purity ≥95%
  • MDL No. MFCD00005707
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃N
  • Molecular Weight 147.22
  • Synonym(s) 2,3-dimethyl-indolin
  • SMILES CC1C(C)NC2=C1C=CC=C2

Description

2,3-Dimethylindoline is a bench-stable, electron-rich heterocycle featuring a fused indoline core with methyl groups at the 2- and 3-positions. This steric and electronic tuning enhances its utility as a building block in synthetic organic chemistry, particularly in the development of functionalized indole derivatives and pharmaceutical intermediates.

Application

2,3-Dimethylindoline serves as a valuable heterocyclic building block in medicinal chemistry, offering enhanced metabolic stability and conformational rigidity compared to unsubstituted indoline. Its benzylic positions enable straightforward functionalization via oxidation or electrophilic substitution, while the nitrogen atom supports diverse derivatization for drug-like scaffolds. Bench-stable and readily purified by column chromatography, it functions effectively in standard coupling and cyclization protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.6041
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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