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CS-W001157 4
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5-Bromo-N-methylpicolinamide

  • CAS No. 845305-87-5

  • Cat. No. CS-0030263
  • Purity≥97%
  • MDL No.MFCD07357421

*For research and further manufacturing use only, not for direct human use.

5-Bromo-N-methylpicolinamide|CS-0030263

Structure of 845305-87-5

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General Information

  • CAS No. 845305-87-5
  • Cat. No. CS-0030263
  • Purity ≥97%
  • MDL No. MFCD07357421
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrN₂O
  • Molecular Weight 215.05
  • Synonym(s) N-Methyl 5-bromopicolinamide
  • SMILES O=C(C1=NC=C(Br)C=C1)NC

Description

5-Bromo-N-methylpicolinamide features a brominated pyridine ring paired with a methylamido group, delivering enhanced electron-withdrawing character and improved solubility in polar solvents. This combination enables efficient coupling reactions and facilitates incorporation into complex heterocyclic scaffolds under standard conditions.

Application

5-Bromo-N-methylpicolinamide serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromo group and amide functionality. The N-methylpyridine-3-carboxamide core provides stability and compatibility with standard synthetic workflows, facilitating efficient access to heterocyclic scaffolds and functionalized analogs for drug discovery applications.

Synthesis

  • Route1
    • In-stock
      5-Bromopicolinic acid|CS-D0613
      30766-11-1
    • null|null
      593-51-1
    • ~64%
    • In-stock
      5-Bromo-N-methylpicolinamide|CS-0030263
      845305-87-5

    References

    • EVOTEC NEUROSCIENCES GMBH Patent: WO2009/135842 A1, 2009 ; Location in patent: Page/Page column 76-77 ; WO 2009/135842 A1
  • Route2
    • In-stock
      Methyl 5-bromopyridine-2-carboxylate|CS-D0954
      29682-15-3
    • null|null
      74-89-5
    • ~99%
    • In-stock
      5-Bromo-N-methylpicolinamide|CS-0030263
      845305-87-5

    References

    • CROWN BIOSCIENCE INC. (TAICANG); ZHONG, Boyu; SHIH, Chuan; YUAN, Hongbin; ZHOU, Feng Patent: WO2014/32498 A1, 2014 ; Location in patent: Page/Page column 10-11 ;
  • Route3

    References

    • WO2013/91096 A1, ; Page/Page column 78 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   1.2037
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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