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CS-W001157 4
Total: USD 88.00

5-Bromopicolinic acid

  • CAS No. 30766-11-1

  • Cat. No. CS-D0613
  • Purity≥96%
  • MDL No.MFCD00234149

*For research and further manufacturing use only, not for direct human use.

5-Bromopicolinic acid|CS-D0613

Structure of 30766-11-1

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General Information

  • CAS No. 30766-11-1
  • Cat. No. CS-D0613
  • Purity ≥96%
  • MDL No. MFCD00234149
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrNO₂
  • Molecular Weight 202.01
  • Synonym(s) 5-Bromo-pyridine-2-carboxylic acid
  • SMILES O=C(O)C(C=C1)=NC=C1Br

Description

5-Bromopicolinic acid features a bromine substituent at the pyridine ring's 5-position, delivering enhanced electrophilicity and facilitating cross-coupling reactions. This bench-stable, moisture-tolerant carboxylic acid integrates readily into synthetic sequences requiring halogenated heterocycles, enabling efficient access to functionalized bioactive scaffolds and advanced intermediates in medicinal chemistry.

Application

5-Bromopicolinic acid serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the pyridine ring via palladium-catalyzed cross-coupling reactions. Its bromine substituent offers high reactivity in Suzuki, Stille, and Negishi couplings, while the carboxylic acid group provides a handle for derivatization or amide formation. The compound exhibits excellent bench stability and facilitates purification by recrystallization, making it well-suited for iterative synthesis of bioactive heterocycles and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5423
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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