Lot numbers can be found on the outside label of a product:
N-Boc-4-oxo-L-proline
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CAS No. 84348-37-8
- Cat. No. CS-M1682
- Purity≥97%
- MDL No.MFCD01860669
*For research and further manufacturing use only, not for direct human use.
Structure of 84348-37-8
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General Information
- CAS No. 84348-37-8
- Cat. No. CS-M1682
- Purity ≥97%
- MDL No. MFCD01860669
- Storage -20°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₅NO₅
- Molecular Weight 229.23
- Synonym(s) Boc-4-oxo-Pro-OH
- SMILES CC(C)(OC(N1CC(C[C@H]1C(O)=O)=O)=O)C
Description
N-Boc-4-oxo-L-proline features a protected amine and a ketone-functionalized pyrrolidine ring, enabling direct incorporation into peptide syntheses. This bench-stable derivative supports efficient access to oxoprolines in bioactive molecule development.
Application
N-Boc-4-oxo-L-proline serves as a versatile building block in peptide synthesis and heterocyclic chemistry, enabling efficient access to pyrrolidine-based scaffolds. The Boc group provides excellent stability and ease of removal under mild acidic conditions, while the 4-oxo functionality supports diverse transformations including reductive amination and nucleophilic addition. Its compatibility with standard coupling protocols and predictable reactivity make it a reliable choice for constructing complex bioactive molecules.
Synthesis
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Route1
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In-stock
13726-69-7 - ~76%
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In-stock
84348-37-8
References
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APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. Patent: WO2004/5249 A1, 2004 ; Location in patent: Page 30-31 ; WO 2004/005249 A1
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Route2
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7664-93-9 -
In-stock
13726-69-7
- ~77%
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In-stock
84348-37-8
References
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Halazy, Serge; Quattropani, Anna; Scheer, Alexander; Schwarz, Mattias; Thomas, Russell; Baxter, Antony Patent: US2003/212012 A1, 2003 ;
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Route3
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In-stock
154456-97-0 - ~88%
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In-stock
84348-37-8
References
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Barraclough, Paul; Hudhomme, Pietrick; Spray, Caroline A.; Young, Douglas W. Tetrahedron, 1995 , vol. 51, # 14 p. 4195 - 4212
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 83.91
- LogP 0.6495
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 1
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Other Classifications
- Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives
- Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives
- Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives
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Key Words
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