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CS-W001157 4
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1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid

  • CAS No. 876317-19-0

  • Cat. No. CS-W018880
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid|CS-W018880

Structure of 876317-19-0

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General Information

  • CAS No. 876317-19-0
  • Cat. No. CS-W018880
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO₅
  • Molecular Weight 229.23
  • Synonym(s) 1,2-pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-dimethylethyl) ester
  • SMILES O=C(C(C1)N(C(OC(C)(C)C)=O)CC1=O)O

Description

This protected pyrrolidinone derivative features a tert-butyl carbamate group that enables stable incorporation into peptide synthesis workflows. The oxopyrrolidine core provides a rigid, electron-deficient scaffold ideal for conformational control in bioactive molecule design.

Application

1-(tert-Butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid serves as a versatile building block for the synthesis of pyrrolidinone-containing scaffolds prevalent in medicinal chemistry. The Boc-protected amine and ketone functionalities enable sequential functionalization, while the stability under standard synthetic conditions facilitates purification and downstream transformations. This compound functions effectively in peptide coupling, heterocycle construction, and as a key intermediate in the development of bioactive molecules requiring precise stereochemical control and functional group compatibility.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   83.91
  • LogP   0.6495
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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