Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

(2S,4S)-1-(tert-Butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid

  • CAS No. 83623-93-2

  • Cat. No. CS-0053415
  • Molecule weight245.27
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2S,4S)-1-(tert-Butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid|CS-0053415

Structure of 83623-93-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 83623-93-2
  • Cat. No. CS-0053415
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₅
  • Molecular Weight 245.27
  • Synonym(s) (2S,4S)-1-tert-Butoxycarbonyl-4-methoxypyrrolidine-2-carboxylic acid
  • SMILES CO[C@H]1C[C@H](N(C1)C(=O)OC(C)(C)C)C(O)=O

Description

This chiral pyrrolidine derivative features a tert-butoxycarbonyl-protected amine and a methoxy-substituted ring, offering a stable, bench-ready scaffold for peptide bond mimicry. The (2S,4S) stereochemistry ensures precise spatial orientation in synthetic sequences, enabling efficient incorporation into bioactive peptides and constrained molecular frameworks under standard conditions.

Application

(2S,4S)-1-(tert-Butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid serves as a stereochemically defined building block for the synthesis of pyrrolidine-based peptidomimetics and bioactive heterocycles. The Boc group provides robust protection of the amine, enabling orthogonal manipulation with the pendant methoxy functionality. Its stability under standard coupling conditions and compatibility with diverse functional groups facilitate efficient access to complex scaffolds in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • In-stock
      N-Boc-cis-4-hydroxy-L-proline|CS-W002886
      87691-27-8
    • null|null
      74-88-4
    • ~73%
    • In-stock
      (2S,4S)-1-(tert-Butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid|CS-0053415
      83623-93-2

    References

    • Scios Inc. Patent: US6288036 B1, 2001 ;
  • Route2
    • (2S,4S)-4-Methoxy-2-(methoxycarbonyl)pyrrolidine-1-carboxylic acid tert-butyl ester|CS-0052779
      215918-38-0
    • ~88%
    • In-stock
      (2S,4S)-1-(tert-Butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid|CS-0053415
      83623-93-2

    References

    • DAIICHI PHARMACEUTICAL CO., LTD. Patent: WO2005/121135 A1, 2005 ; Location in patent: Page/Page column 52 ;
  • Route3
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      75176-19-1
    • ~%
    • In-stock
      (2S,4S)-1-(tert-Butoxycarbonyl)-4-methoxypyrrolidine-2-carboxylic acid|CS-0053415
      83623-93-2

    References

    • EP1757602 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   76.07
  • LogP   1.0954
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 83623-93-2 sigma83623-93-2 manufacturer83623-93-2 price83623-93-2 structure83623-93-2 SDSbuy 83623-93-283623-93-2 supplier83623-93-2 uses83623-93-2 molecular weightprice of 83623-93-283623-93-2 chemical name formula of 83623-93-2
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label