Lot numbers can be found on the outside label of a product:
3,6-Dichloropyridazin-4-amine
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CAS No. 823-58-5
- Cat. No. CS-D0781
- Purity≥98%
- MDL No.MFCD01647253
*For research and further manufacturing use only, not for direct human use.
Structure of 823-58-5
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General Information
- CAS No. 823-58-5
- Cat. No. CS-D0781
- Purity ≥98%
- MDL No. MFCD01647253
- Storage -20°C, sealed storage, away from moisture and light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₃Cl₂N₃
- Molecular Weight 163.99
- Synonym(s) NSC 170664; 4-pyridazinamine, 3,6-dichloro-
- SMILES NC1=CC(Cl)=NN=C1Cl
Description
3,6-Dichloropyridazin-4-amine is a bench-stable heterocyclic amine featuring two chlorine substituents at the 3 and 6 positions of the pyridazine core. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions and serves as a key building block in medicinal chemistry for kinase inhibitors and agrochemicals.
Application
3,6-Dichloropyridazin-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through nucleophilic substitution and cross-coupling reactions. Its dual chlorine substituents provide orthogonal reactivity for sequential functionalization, while the pyridazinamine core offers excellent stability and compatibility with common reaction conditions. The compound facilitates efficient access to substituted pyridazines used in agrochemicals and pharmaceutical scaffolds.
Synthesis
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Route1
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In-stock
6082-66-2 - ~35%
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In-stock
823-58-5
References
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Booker, Shon; Kim, Tae-Seong; Liao, Hongyu; Liu, Longbin; Norman, Mark H.; Peterson, Emily Anne; Stec, Markian; Tamayo, Nuria A. Patent: US2009/163489 A1, 2009 ; Location in patent: Page/Page column 51 ; US 20090163489 A1
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Route2
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In-stock
887310-61-4 - ~97%
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In-stock
823-58-5
References
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Guetzoyan, Lucie; Ingham, Richard J.; Nikbin, Nikzad; Rossignol, Julien; Wolling, Michael; Baumert, Mark; Burgess-Brown, Nicola A.; Strain-Damerell, Claire M.; Shrestha, Leela; Brennan, Paul E.; Fedorov, Oleg; Knapp, Stefan; Ley, Steven V. MedChemComm, 2014 , vol. 5, # 4 p. 540 - 546
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Route3
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17285-22-2 - ~%
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In-stock
823-58-5
References
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Chemical and Pharmaceutical Bulletin, , vol. 6, p. 641,644
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 51.8
- LogP 1.3656
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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