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CS-W001157 4
Total: USD 88.00

3,5-Dichloropyridazin-4-amine

  • CAS No. 53180-76-0

  • Cat. No. CS-W018823
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,5-Dichloropyridazin-4-amine|CS-W018823

Structure of 53180-76-0

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General Information

  • CAS No. 53180-76-0
  • Cat. No. CS-W018823
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃Cl₂N₃
  • Molecular Weight 163.99
  • Synonym(s) None
  • SMILES NC1=C(Cl)C=NN=C1Cl

Description

3,5-Dichloropyridazin-4-amine features a rigid heteroaromatic core with two chlorine substituents positioned at electron-deficient sites, enabling selective coupling in cross-coupling reactions. This bench-stable scaffold integrates readily into bioactive molecules, offering enhanced metabolic stability and improved solubility in polar solvents for medicinal chemistry applications.

Application

3,5-Dichloropyridazin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution and cross-coupling reactions. Its dual chloro groups offer orthogonal reactivity for sequential functionalization, while the pyridazinamine core provides a stable, bench-compatible platform for further derivatization in API development.

Synthesis

  • Route1

    References

    • Journal of Heterocyclic Chemistry, , vol. 32, # 5 p. 1423 - 1428
  • Route2

    References

    • Pharmaceutical Bulletin, , vol. 4, p. 497

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.3656
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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