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CS-W001157 4
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3-(Pyridin-2-yl)-1H-1,2,4-triazol-5-amine

  • CAS No. 83417-23-6

  • Cat. No. CS-0096022
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Pyridin-2-yl)-1H-1,2,4-triazol-5-amine|CS-0096022

Structure of 83417-23-6

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General Information

  • CAS No. 83417-23-6
  • Cat. No. CS-0096022
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₅
  • Molecular Weight 161.16
  • Synonym(s) 5-(pyridin-2-yl)-4H-1,2,4-triazol-3-amine
  • SMILES NC1=NC(C2=NC=CC=C2)=NN1

Description

This triazole derivative features a pyridin-2-yl group at the 3-position, enhancing solubility and enabling coordination in metal complexes. The 1H-1,2,4-triazol-5-amine core provides strong hydrogen-bonding capacity and acts as a versatile ligand in catalysis and medicinal chemistry applications.

Application

3-(Pyridin-2-yl)-1H-1,2,4-triazol-5-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization protocols. Its pyridyl-triazole architecture offers enhanced solubility and hydrogen-bonding capacity, facilitating interactions with biological targets. The compound exhibits bench stability, tolerates diverse reaction conditions, and is amenable to purification via standard chromatographic methods, making it well-suited for iterative synthesis campaigns in drug discovery.

Synthesis

  • Route1
    • null|null
      83417-22-5
    • ~93%
    • In-stock
      3-(Pyridin-2-yl)-1H-1,2,4-triazol-5-amine|CS-0096022
      83417-23-6

    References

    • Lipinski, Christopher A. Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 1 - 6
  • Route2
    • 2-Pyridinecarbohydrazide Isoniazid  Impurity|CS-0229452
      1452-63-7
    • ~%
    • In-stock
      3-(Pyridin-2-yl)-1H-1,2,4-triazol-5-amine|CS-0096022
      83417-23-6

    References

    • Journal of Medicinal Chemistry, , vol. 26, # 1 p. 1 - 6
  • Route3
    • null|null
      1354647-03-2
    • ~%
    • In-stock
      3-(Pyridin-2-yl)-1H-1,2,4-triazol-5-amine|CS-0096022
      83417-23-6

    References

    • Chernyshev; Tarasova; Chernysheva; Taranushich Russian Journal of Applied Chemistry, 2011 , vol. 84, # 11 p. 1890 - 1896

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   80.48
  • LogP   0.4489
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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