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CS-W001157 4
Total: USD 88.00

Fmoc-Ser-OMe

  • CAS No. 82911-78-2

  • Cat. No. CS-0103666
  • Purity≥98%
  • MDL No.MFCD00672334

*For research and further manufacturing use only, not for direct human use.

Fmoc-Ser-OMe|CS-0103666

Structure of 82911-78-2

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General Information

  • CAS No. 82911-78-2
  • Cat. No. CS-0103666
  • Purity ≥98%
  • MDL No. MFCD00672334
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₉NO₅
  • Molecular Weight 341.36
  • Synonym(s) Fmoc-L-Ser-OMe
  • SMILES OC[C@@H](C(OC)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

Fmoc-Ser-OMe delivers a protected serine derivative with a labile methyl ester, enabling selective deprotection during peptide synthesis. The fluorenylmethoxy carbonyl (Fmoc) group ensures orthogonal handling, while the OMe functionality simplifies downstream manipulation. This reagent integrates efficiently into solid-phase workflows under standard conditions.

Application

Fmoc-Ser-OMe serves as a key building block in peptide synthesis, offering orthogonal protection for both the amine and hydroxyl functionalities. The Fmoc group enables efficient base-labile deprotection, while the methyl ester facilitates selective derivatization or downstream processing. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for solid-phase and solution-phase peptide assembly.

Synthesis

  • Route1

    References

    • Shao, Hui; Lockman, Jeffrey W.; Parquette, Jon R. Journal of the American Chemical Society, 2007 , vol. 129, # 7 p. 1884 - 1885
  • Route2
    • In-stock
      Fmoc-Ser-OH|CS-W007720
      73724-45-5
    • null|null
      74-88-4
    • ~94%
    • In-stock
      Fmoc-Ser-OMe|CS-0103666
      82911-78-2

    References

    • Zhang, Fa; Zhang, Wei; Zhang, Yan; Curran, Dennis P.; Liu, Gang Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2594 - 2597
  • Route3
    • null|null
      186581-53-3
    • In-stock
      Fmoc-Ser-OH|CS-W007720
      73724-45-5
    • ~%
    • In-stock
      Fmoc-Ser-OMe|CS-0103666
      82911-78-2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1421 - 1428

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   2.059
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   5

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