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CS-W001157 4
Total: USD 88.00

L-Serine methyl ester hydrochloride

  • CAS No. 5680-80-8

  • Cat. No. CS-B1301
  • Purity≥97%
  • MDL No.MFCD00063680

*For research and further manufacturing use only, not for direct human use.

L-Serine methyl ester hydrochloride|CS-B1301

Structure of 5680-80-8

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General Information

  • CAS No. 5680-80-8
  • Cat. No. CS-B1301
  • Purity ≥97%
  • MDL No. MFCD00063680
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀ClNO₃
  • Molecular Weight 155.58
  • Synonym(s) None
  • SMILES O=C(OC)[C@H](CO)N.[H]Cl

Description

L-Serine methyl ester (hydrochloride) offers a stable, moisture-tolerant platform for peptide synthesis, featuring a protected hydroxyl group and a protonated amine that simplifies purification. This bench-stable derivative enables efficient incorporation into peptide chains under standard conditions.

Application

L-Serine methyl ester (hydrochloride) serves as a key chiral building block in peptide synthesis and heterocyclic chemistry, offering well-established reactivity for nucleophilic acyl substitution and amide bond formation. Its hydrochloride salt enhances bench stability and simplifies handling, while the protected hydroxyl group enables selective derivatization. This compound facilitates efficient access to serine-containing peptides and β-lactam scaffolds under standard synthetic conditions.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      H-Ser-OH Amino acid impurity|CS-1733142
      56-45-1
    • ~98%
    • In-stock
      L-Serine methyl ester hydrochloride|CS-B1301
      5680-80-8

    References

    • Tetrahedron, , vol. 50, # 31 p. 9411 - 9424
  • Route2
    • null|null
      111934-17-9
    • ~87%
    • In-stock
      L-Serine methyl ester hydrochloride|CS-B1301
      5680-80-8

    References

    • Journal of Organic Chemistry, , vol. 55, # 8 p. 2271 - 2272
  • Route3
    • null|null
      67-56-1
    • In-stock
      L-Serine hydrochloride|CS-0201873
      16428-75-4
    • ~99%
    • In-stock
      L-Serine methyl ester hydrochloride|CS-B1301
      5680-80-8

    References

    • Chemical Communications, , vol. 46, # 3 p. 445 - 447

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   -1.0992
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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