H-D-Ser-OMe.HCl

Name: H-D-Ser-OMe.HCl
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 5874-57-7
Cat. No. CS-W016249
Purity≥96%
MDL No.MFCD00066121

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 5874-57-7

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General Information

CAS No. 5874-57-7
Cat. No. CS-W016249
Purity ≥96%
MDL No. MFCD00066121
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₁₀ClNO₃
Molecular Weight 155.58
Synonym(s) None
SMILES COC([C@@](N)([H])CO)=O.Cl

Description

H-D-Ser-OMe.HCl features a stable D-serine backbone with a methyl ester group, enabling efficient incorporation into peptide sequences. This bench-stable derivative enhances solubility and simplifies purification in synthetic workflows. The hydrochloride salt ensures excellent handling properties and compatibility with standard peptide coupling conditions.

Application

H-D-Ser-OMe·HCl serves as a stable, bench-ready building block for peptide synthesis, enabling efficient incorporation of D-serine residues with predictable stereochemical control. The methyl ester group facilitates downstream derivatization, while the hydrochloride salt ensures excellent solubility and handling. This derivative functions reliably in standard coupling protocols and supports orthogonal protection strategies in complex peptide assembly.

Synthesis

Route1
- 67-56-1
- 312-84-5
- ~99%
- In-stock
  
  5874-57-7
References
- Morieux, Pierre; Salome, Christophe; Park, Ki Duk; Stables, James P.; Kohn, Harold Journal of Medicinal Chemistry, 2010 , vol. 53, # 15 p. 5716 - 5726
Route2
- 67-56-1
- 312-84-5
- 75-36-5
- ~97%
- In-stock
  
  5874-57-7
References
- Kim, Hee-Kwon; Park, Kyoung-Joo Jenny Tetrahedron Letters, 2012 , vol. 53, # 13 p. 1668 - 1670

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 72.55
LogP -1.0992
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Serine and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

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H-D-Ser-OMe.HCl

CAS No. 5874-57-7

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