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CS-W001157 4
Total: USD 88.00

4-Fluorobenzamide

  • CAS No. 824-75-9

  • Cat. No. CS-W016478
  • Purity≥97%
  • MDL No.MFCD00007992

*For research and further manufacturing use only, not for direct human use.

4-Fluorobenzamide|CS-W016478

Structure of 824-75-9

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General Information

  • CAS No. 824-75-9
  • Cat. No. CS-W016478
  • Purity ≥97%
  • MDL No. MFCD00007992
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO
  • Molecular Weight 139.13
  • Synonym(s) 4-Fluoro Benamide
  • SMILES C1=CC(=CC=C1C(N)=O)F

Description

4-Fluorobenzamide features a para-fluoro substituent on a benzamide scaffold, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables reliable incorporation into pharmaceutical intermediates and bioactive molecule frameworks under standard conditions.

Application

4-Fluorobenzamide serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard amide coupling and electrophilic substitution reactions. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient incorporation into API candidates and heterocyclic systems.

Synthesis

  • Route1
    • In-stock
      4-Iodofluorobenzene|CS-D1411
      352-34-1
    • null|null
      201230-82-2
    • ~95%
    • In-stock
      4-Fluorobenzamide|CS-W016478
      824-75-9

    References

    • Xu, Tongyu; Alper, Howard Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5496 - 5499
  • Route2

    References

    • Sun, Chunlou; Qu, Panpan; Li, Feng Catalysis Science and Technology, 2014 , vol. 4, # 4 p. 988 - 996
  • Route3
    • null|null
      1063716-69-7
    • ~79%
    • In-stock
      4-Fluorobenzamide|CS-W016478
      824-75-9

    References

    • PRESIDENT AND FELLOWS OF HARVARD COLLEGE Patent: WO2009/100014 A1, 2009 ; Location in patent: Page/Page column 171-173; 193 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   0.9246
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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