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CS-W001157 4
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3,5-Difluorobenzamide

  • CAS No. 132980-99-5

  • Cat. No. CS-0194789
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,5-Difluorobenzamide|CS-0194789

Structure of 132980-99-5

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General Information

  • CAS No. 132980-99-5
  • Cat. No. CS-0194789
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO
  • Molecular Weight 157.12
  • Synonym(s) Difluorobenzamide6
  • SMILES FC1=CC(F)=CC(C(N)=O)=C1

Description

3,5-Difluorobenzamide delivers a sterically unhindered aromatic scaffold with electron-withdrawing fluorine substituents at the meta positions. This configuration enhances metabolic stability and modulates electronic properties for use in medicinal chemistry. The amide functionality enables direct incorporation into peptide-like systems or coupling reactions under standard conditions.

Application

3,5-Difluorobenzamide serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds prevalent in pharmaceuticals. Its stability under standard reaction conditions and compatibility with diverse coupling protocols facilitate efficient incorporation into target molecules. The ortho-difluoro substitution pattern enhances metabolic stability and modulates electronic properties, offering predictable reactivity in amide bond formation and electrophilic substitution processes.

Synthesis

  • Route1

    References

    • University Court of The University of St. Andrews; Nolan, Steven P. Patent: US2013/35322 A1, 2013 ; Location in patent: Paragraph 0112 ;
  • Route2

    References

    • Enthaler, Stephan; Weidauer, Maik; Schroeder, Fanny Tetrahedron Letters, 2012 , vol. 53, # 7 p. 882 - 885
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 34, # 5 p. 1630 - 1633

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.0637
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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