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CS-W001157 4
Total: USD 88.00

(S)-Methyl 3-hydroxy-2-methylpropanoate

  • CAS No. 80657-57-4

  • Cat. No. CS-W023098
  • Purity≥97%
  • MDL No.MFCD00064520

*For research and further manufacturing use only, not for direct human use.

(S)-Methyl 3-hydroxy-2-methylpropanoate|CS-W023098

Structure of 80657-57-4

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General Information

  • CAS No. 80657-57-4
  • Cat. No. CS-W023098
  • Purity ≥97%
  • MDL No. MFCD00064520
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀O₃
  • Molecular Weight 118.13
  • Synonym(s) Methyl (S)-(+)-3-Hydroxyisobutyrate
  • SMILES O=C(OC)[C@@H](C)CO

Description

Methyl (S)-(+)-3-hydroxy-2-methylpropionate may be used as a starting material in the total synthesis of (+)-discodermolide, a potent antimitotic agent.

Synthesis

  • Route1

    References

    • Wassenaar, Jeroen; Kuil, Mark; Reek, Joost N. H. Advanced Synthesis and Catalysis, 2008 , vol. 350, # 10 p. 1610 - 1614
  • Route2

    References

    • Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 185 - 189
  • Route3
    • null|null
      73295-10-0
    • ~74%
    • In-stock
      (S)-Methyl 3-hydroxy-2-methylpropanoate|CS-W023098
      80657-57-4

    References

    • Czeskis, Boris A.; Moissenkov, Alexander M. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1353 - 1354

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   -0.2122
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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