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CS-W001157 4
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(R)-Methyl 3-hydroxy-2-methylpropanoate

  • CAS No. 72657-23-9

  • Cat. No. CS-0019967
  • Purity≥96%
  • MDL No.MFCD00063450

*For research and further manufacturing use only, not for direct human use.

(R)-Methyl 3-hydroxy-2-methylpropanoate|CS-0019967

Structure of 72657-23-9

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General Information

  • CAS No. 72657-23-9
  • Cat. No. CS-0019967
  • Purity ≥96%
  • MDL No. MFCD00063450
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀O₃
  • Molecular Weight 118.13
  • Synonym(s) (-)-(R)-Roche ester; (-)-Methyl β-hydroxyisobutyrate; (2R)-3-Hydroxy-2-methylpropionic acid methyl ester; (R)-(-)-3-Hydroxy-2-methylpropionic acid methyl ester; Methyl (R)-(-)-3-Hydroxy-2-methylpropionate
  • SMILES COC([C@H](C)CO)=O

Description

Methyl (R)-(-)-3-hydroxy-2-methylpropionate may be used in the preparation of (S)-(4-benzyloxy-3-methylbut-1-ynyl)triethylsilane. It may also be used as a starting material in the total synthesis of (-)-discodermolide, (-)-stemoamide and (-)-stemospironine.

Synthesis

  • Route1

    References

    • Tetrahedron Asymmetry, , vol. 20, # 2 p. 210 - 213
  • Route2

    References

    • Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 185 - 189
  • Route3
    • null|null
      64809-29-6
    • ~%
    • In-stock
      (S)-Methyl 3-hydroxy-2-methylpropanoate|CS-W023098
      80657-57-4
    • In-stock
      (R)-Methyl 3-hydroxy-2-methylpropanoate|CS-0019967
      72657-23-9

    References

    • Advanced Synthesis and Catalysis, , vol. 350, # 16 p. 2533 - 2543

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   -0.2122
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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