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CS-W001157 4
Total: USD 88.00

4-Isopropylthiazol-2-amine

  • CAS No. 79932-20-0

  • Cat. No. CS-0061030
  • Purity≥98%
  • MDL No.MFCD07625985

*For research and further manufacturing use only, not for direct human use.

4-Isopropylthiazol-2-amine|CS-0061030

Structure of 79932-20-0

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General Information

  • CAS No. 79932-20-0
  • Cat. No. CS-0061030
  • Purity ≥98%
  • MDL No. MFCD07625985
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀N₂S
  • Molecular Weight 142.22
  • Synonym(s) 4-Isopropyl-1,3-thiazol-2-amine
  • SMILES NC1=NC(C(C)C)=CS1

Description

4-Isopropylthiazol-2-amine features a thiazole core with a para-amino group and a sterically hindered isopropyl substituent, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into bioactive molecule design, offering a robust platform for pharmaceutical development.

Application

4-Isopropylthiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to thiazole-based scaffolds. Its amine functionality facilitates straightforward derivatization and salt formation, while the isopropyl group enhances metabolic stability and lipophilicity. The compound exhibits good bench stability and compatibility with common coupling reactions, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1
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      17356-08-0
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      19967-55-6
    • ~%
    • In-stock
      4-Isopropylthiazol-2-amine|CS-0061030
      79932-20-0

    References

    • Journal of the Chemical Society, , p. 2430,2440
  • Route2
    • null|null
      76002-26-1
    • null|null
      17356-08-0
    • ~84%
    • In-stock
      4-Isopropylthiazol-2-amine|CS-0061030
      79932-20-0

    References

    • Gasteiger, Johann; Herzig, Christian Tetrahedron, 1981 , vol. 37, # 15 p. 2607 - 2611
  • Route3
    • null|null
      19967-55-6
    • ~%
    • In-stock
      4-Isopropylthiazol-2-amine|CS-0061030
      79932-20-0

    References

    • US2009/143448 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.8487
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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