Lot numbers can be found on the outside label of a product:
4-tert-Butyl-1,3-thiazol-2-amine
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CAS No. 74370-93-7
- Cat. No. CS-0037875
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 74370-93-7
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General Information
- CAS No. 74370-93-7
- Cat. No. CS-0037875
- Purity ≥98%
- MDL No. None
- Storage RT, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₁₂N₂S
- Molecular Weight 156.25
- Synonym(s) 4-(tert-Butyl)-1,3-thiazol-2-amine
- SMILES CC(C)(C)C1=CSC(=N1)N
Description
4-tert-Butyl-1,3-thiazol-2-amine features a sterically hindered tert-butyl group that enhances solubility and stability in organic media. The thiazole core provides a robust scaffold for heterocyclic synthesis, while the amine functionality enables direct coupling reactions. This compound serves as a key building block in medicinal chemistry and materials science applications.
Application
4-tert-Butyl-1,3-thiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry and synthetic organic chemistry. Its stable tert-butyl group enhances solubility and steric profile, while the thiazole-amino functionality enables diverse transformations, including coupling reactions, electrophilic substitutions, and transition-metal-catalyzed cross-couplings. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for modular synthesis of bioactive scaffolds and functionalized pharmaceutical intermediates.
Synthesis
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Route1
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In-stock
5469-26-1 -
17356-08-0 - ~90%
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In-stock
74370-93-7
References
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Institute of Medicinal Molecular Design, Inc. Patent: EP1514544 A1, 2005 ; Location in patent: Page/Page column 152 ;
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Route2
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In-stock
5469-26-1
- ~92%
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In-stock
74370-93-7
References
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Institute of Medicinal Molecular Design, Inc. Patent: EP1352650 A1, 2003 ;
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Route3
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6832-15-1
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17356-08-0
- ~87%
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In-stock
74370-93-7
References
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Yadav; Reddy, B.V. Subba; Rao, Y. Gopala; Narsaiah Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2381 - 2383
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.91
- LogP 2.0228
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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