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CS-W001157 4
Total: USD 88.00

6-Thio-2'-Deoxyguanosine

  • CAS No. 789-61-7

  • Cat. No. CS-0014289
  • Purity≥98%
  • MDL No.MFCD00672275

*For research and further manufacturing use only, not for direct human use.

6-Thio-2'-Deoxyguanosine|CS-0014289

Structure of 789-61-7

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General Information

  • CAS No. 789-61-7
  • Cat. No. CS-0014289
  • Purity ≥98%
  • MDL No. MFCD00672275
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃N₅O₃S
  • Molecular Weight None
  • Synonym(s) 6-thio-dG; β-TGdR
  • SMILES OC[C@@H]1[C@H](C[C@H](N2C=NC3=C2NC(N)=NC3=S)O1)O

Description

Intercalating into telomeric DNA repeats, 6-Thio-2′-Deoxyguanosine (CAS 789-61-7) induces replication stress and triggers senescence in proliferating cell lines through aberrant telomere elongation.

Application

6-Thio-2′-Deoxyguanosine (CAS 789-61-7) enables real-time monitoring of secreted luciferase activity in tonsillar cancer cells by integrating into DNA and triggering detectable luminescence upon metabolic activation. This allows precise tracking of tumor cell proliferation. Researchers exploit this feature to evaluate drug efficacy in live-cell assays.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   122.21
  • LogP   -0.28821
  • H_Acceptors   8
  • H_Donors   4
  • Rotatable_Bonds   2

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