Lot numbers can be found on the outside label of a product:
Pittsburgh Compound B
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CAS No. 566169-93-5
- Cat. No. CS-0092545
- Purity≥95%
- MDL No.MFCD17018727
*For research and further manufacturing use only, not for direct human use.
Structure of 566169-93-5
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General Information
- CAS No. 566169-93-5
- Cat. No. CS-0092545
- Purity ≥95%
- MDL No. MFCD17018727
- Storage 4°C, protect from light, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₄H₁₂N₂OS
- Molecular Weight 256.33
- Synonym(s) PiB; 6-OH-BTA-1
- SMILES OC1=CC=C2N=C(SC2=C1)C3=CC=C(C=C3)NC
Description
Pittsburgh Compound B delivers high-affinity binding to cerebral amyloid-beta plaques, enabling non-invasive visualization of Alzheimer’s disease pathology via PET imaging. This radiolabeled tracer features a benzoylpyrrolidine scaffold with optimized pharmacokinetics for rapid brain penetration and clearance of background signal.
Application
Pittsburgh Compound B serves as a well-established radioligand for in vivo imaging of beta-amyloid plaques in Alzheimer’s disease research. Its high binding affinity and selectivity for fibrillar amyloid-beta enable reliable positron emission tomography (PET) visualization, facilitating longitudinal studies of neurodegenerative progression. The compound exhibits favorable pharmacokinetics and metabolic stability in preclinical models, supporting consistent target engagement and signal-to-background ratios.
Synthesis
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Route1
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![[4-(6-Methoxy-Benzothiazol-2-yl)-phenyl]-methyl-amine|CS-0770224](https://file.chemscene.com/productPIC/CS-0770224.gif)
401813-34-1 - ~96%
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In-stock
566169-93-5
References
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Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun Patent: US2012/214994 A1, 2012 ; Location in patent: Page/Page column 14 ;
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Route2
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1071832-31-9 - ~61%
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In-stock
566169-93-5
References
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Zheng, Ming-Qiang; Yin, Duan-Zhi; Qiao, Jin-Ping; Zhang, Lan; Wang, Yong-Xian Journal of Fluorine Chemistry, 2008 , vol. 129, # 3 p. 210 - 216
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Route3
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In-stock
1747-60-0 - ~%
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In-stock
566169-93-5
References
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Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H332-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 45.15
- LogP 3.7106
- H_Acceptors 4
- H_Donors 2
- Rotatable_Bonds 2
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Key Words
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