6-Thioguanosine

Name: 6-Thioguanosine
Brand: ChemScene
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CAS No. 85-31-4
Cat. No. CS-0068553
Purity≥95%
MDL No.MFCD23102202

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 85-31-4
Cat. No. CS-0068553
Purity ≥95%
MDL No. MFCD23102202
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₃N₅O₄S
Molecular Weight 299.31
Synonym(s) 6-Mercaptoguanosine
SMILES NC1=NC(C2=C(N1)N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=S

Description

6-Thioguanosine integrates a thiopurine scaffold with enhanced metabolic stability and targeted incorporation into nucleic acids. This analog features a sulfur substitution at the C6 position, enabling selective engagement in DNA/RNA synthesis pathways. The modified base pairs efficiently with cytosine while resisting enzymatic degradation, making it valuable for probing nucleic acid dynamics and developing site-specific probes.

Application

6-Thioguanosine serves as a valuable nucleoside building block for the synthesis of thiopurine analogs and thio-modified oligonucleotides. Its thiol group at the C6 position enables site-specific conjugation and metal coordination, facilitating applications in probe development and targeted delivery systems. The molecule exhibits good bench stability and compatibility with standard deprotection protocols, enabling straightforward incorporation into complex synthetic sequences.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 142.44
LogP -1.31741
H_Acceptors 9
H_Donors 5
Rotatable_Bonds 2

Other Classifications

Life Science Nucleosides & Nucleotides Nucleosides, Deoxyribonucleosides and Other Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

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6-Thioguanosine

CAS No. 85-31-4

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