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CS-W001157 4
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4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate Gefitinib Impurity

  • CAS No. 788136-89-0

  • Cat. No. CS-0229028
  • Purity≥98%
  • MDL No.MFCD11618121

*For research and further manufacturing use only, not for direct human use.

4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate Gefitinib Impurity|CS-0229028

Structure of 788136-89-0

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General Information

  • CAS No. 788136-89-0
  • Cat. No. CS-0229028
  • Purity ≥98%
  • MDL No. MFCD11618121
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₃ClFN₃O₃
  • Molecular Weight 361.75
  • Synonym(s) Gefitinib interMediate VI
  • SMILES CC(=O)OC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC

Synthesis

  • Route1

    References

    • Ban, Hyun Seung; Tanaka, Yuko; Nabeyama, Wataru; Hatori, Masako; Nakamura, Hiroyuki Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 870 - 879
  • Route2

    References

    • Luk, Kin-Chun; Zhang, Zhuming Patent: US2004/254205 A1, 2004 ; Location in patent: Page 18-19 ; US 20040254205 A1
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 14 p. 1911 - 1914

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   73.34
  • LogP   4.0998
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   4

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