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CS-W001157 4
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7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate

  • CAS No. 179688-53-0

  • Cat. No. CS-0064069
  • Purity≥97%
  • MDL No.MFCD09833010

*For research and further manufacturing use only, not for direct human use.

7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate|CS-0064069

Structure of 179688-53-0

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General Information

  • CAS No. 179688-53-0
  • Cat. No. CS-0064069
  • Purity ≥97%
  • MDL No. MFCD09833010
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₂O₄
  • Molecular Weight 234.21
  • Synonym(s) 6-Acetoxy-7-methoxy-4-quinazolinol
  • SMILES O=C1NC=NC2=C1C=C(OC(C)=O)C(OC)=C2

Description

7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate features a fused quinazoline core with a methoxy group at C7 and an acetyl ester at C6, conferring enhanced solubility and metabolic stability. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibition and exhibits favorable handling properties under standard bench conditions.

Application

7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate serves as a versatile building block in medicinal chemistry, enabling direct access to quinazoline-based pharmacophores. The acetyl group provides enhanced solubility and metabolic stability while maintaining compatibility with standard coupling and functionalization reactions. Bench-stable and readily purified by recrystallization, it functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   81.28
  • LogP   0.857
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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