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Structure of 785777-89-1
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4-Bromo-6-(trifluoromethyl)pyrimidine is a bench-stable, electron-deficient heterocycle featuring a bromine at the 4-position and a trifluoromethyl group at the 6-position. This combination enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive molecules requiring enhanced metabolic stability and lipophilicity.
4-Bromo-6-(trifluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions with high efficiency. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the trifluoromethyl substituent enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing complex heterocyclic scaffolds in API development.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: